Interleukin-2 Signaling and Inherited Immunodeficiency
نویسندگان
چکیده
منابع مشابه
Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals.
Infection with HIV results in an incremental loss of T helper cell (TH) function, which can occur years before CD4 cell numbers are critically reduced and AIDS is diagnosed. All TH function is not affected, however, because B cell activation and hypergammaglobulinema are also characteristic of this period. Recently, in a murine model of AIDS an early loss in production of the CD4 cytokines IL-2...
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Cytokines may have clinical utility as therapeutic agents for human immunodeficiency virus type 1 (HIV-1) infection and as an adjuvant for vaccines. The effect of interleukin-12 (IL-12) and IL-15 on in vitro HIV-1 replication was investigated. IL-12 and IL-15 at doses up to 10 ng/ml had little effect on basal HIV-1 p24 antigen production by chronically HIV-infected T (ACH-2) and monocytic (U1) ...
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From the 'Charing Cross and Westminster Medical School, London, UK; 1RCCS Maggiore Hospital, Milan, Italy; Beth Israel Hospital, Boston USA; Universitv Hospital Leiden, The Netherlands; Research Centre of Medical Genetics, Moscow, The Russian Federation; WHO, Switzerland; Christian Medical College Hospital, Vellore, India; University of Lund, Malmö, Sweden; 'Institute of Clinical Genetics, Mosc...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 1999
ISSN: 0002-9297
DOI: 10.1086/302518